Lamin B1 Rabbit Polyclonal Antibody

Function

Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Lamin B, along with heterochromatin, is anchored to the inner surface of the nuclear membrane by the lamin B receptor. LMNB1 has been shown to interact with Thymopoietin.

Background References

1. "Structural organization of the human gene (LMNB1) encoding nuclear lamin B1." Lin F., Worman H.J. Genomics 27:230-236(1995)

2. "Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1." Ruan J., Xu C., Bian C., Lam R., Wang J.P., Kania J., Min J., Zang J. FEBS Lett. 586:314-318(2012)

Sequence Similarity

Belongs to the intermediate filament family.

Post-translational Modification

B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

Subcellular Location

Intermediate filament, Nucleus.

UNIPROT

SwissProt: P20700 Human

Synonyms

ADLD antibody

lamin B1 antibody

Lamin-B1 antibody

LMN antibody

LMN2 antibody

LMNB antibody

Lmnb1 antibody

LMNB1_HUMAN antibody

MGC111419 antibody

OTTHUMP00000159218 antibody