LT-alpha Mouse Monoclonal Antibody [C2-F2]

Function

Lymphotoxin-alpha (LTA), a member of the tumor necrosis factor (TNF) family of cytokines, was initially isolated on the basis of an anti-tumor activity. LTA plays a key role in communication between lymphocytes and stromal cells, thereby eliciting cytotoxic effects on cancer cells. It induces the expression of vascular cell-adhesion molecule 1 (VCAM1) on vascular endothelial cells and recruits natural killer (NK) cells to parenchymal organs and tumor lesions.

Background References

1. Gray PW, Aggarwal BB , Benton CV , et al . Cloning and expression of cDNA for human lymphotoxin , a lymphokine with tumor necrosis activity [J ] . Nat ure , 1984 , 312 (20) : 723 - 724.

2. Kobayashi Y., Miyamoto D., Asada M., Obinata M., Osawa T.; "Cloning and expression of human lymphotoxin mRNA derived from a human T cell hybridoma."; J. Biochem. 100:727-733(1986).

3. Messer G., Spengler U., et al. "Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production."; J. Exp. Med. 173:209-219(1991).

Sequence Similarity

Belongs to the tumor necrosis factor family.

Subcellular Location

Secretory

UNIPROT

SwissProt: P01374 Human

Synonyms