LT-alpha Mouse Monoclonal Antibody [6-C10-10]
Catalog# M0807-15
LT-alpha Mouse Monoclonal Antibody [6-C10-10]
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WB
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Human
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Rat
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unconjugated
Overview
Product Name
LT-alpha Mouse Monoclonal Antibody [6-C10-10]
Antibody Type
Mouse Monoclonal Antibody
Immunogen
Synthetic peptide within Human LT-alpha aa 51-100 / 205.
Species Reactivity
Human, Rat
Validated Applications
WB
Target Molecular Weight
18 kDa
Positive Control
Recombinant LT-alpha(TNF-β)
Conjugation
unconjugated
Clone Number
6-C10-10
RRID
Product Features
Form
Liquid
Concentration
2 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 25% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG1
Purification Method
Protein A affinity purified.
Application Dilution
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ELISA
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1:10,000 WB: 1:500
Target
Function
Lymphotoxin-alpha (LTA), a member of the tumor necrosis factor (TNF) family of cytokines, was initially isolated on the basis of an anti-tumor activity. LTA plays a key role in communication between lymphocytes and stromal cells, thereby eliciting cytotoxic effects on cancer cells. It induces the expression of vascular cell-adhesion molecule 1 (VCAM1) on vascular endothelial cells and recruits natural killer (NK) cells to parenchymal organs and tumor lesions.
Background References
1. Bell G.I., Pictet R.L., Rutter W.J., Cordell B., Tischer E., Goodman H.M.;"Sequence of the human insulin gene.";Nature 284:26-32(1980).
2. Nicol D.S.H.W., Smith L.F.;"Amino-acid sequence of human insulin.";Nature 187:483-485(1960).
3. Chang X., Joergensen A.M., Bardrum P., Led J.J.;"Solution structures of the R6 human insulin hexamer."; Biochemistry 36:9409-9422(1997).
Sequence Similarity
Belongs to the tumor necrosis factor family.
Subcellular Location
Secretory
UNIPROT
Synonyms
LTalpha antibody
DIF antibody
LT alpha antibody
LT antibody
LT-alpha antibody
Lta antibody
Lymphotoxin alpha (TNF superfamily, member 1) antibody
Lymphotoxin alpha antibody
Lymphotoxin-alpha antibody
TNF B antibody
ExpandImages
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Western blot analysis on recombinant LT-alpha (TNF-β) using anti- LT-alpha monoclonal antibody.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Products with the same target and pathway
LT-alpha Mouse Monoclonal Antibody [C2-F2]
Application: WB
Reactivity: Human
Conjugate: unconjugated
