CCDC111 Mouse Monoclonal Antibody [10-B3]

Function

DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. PRIMPOL shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. It is involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. PRIMPOL is required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. PRIMPOL has non-overlapping function with POLH.

Background References

1. "hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity." Wan L., Lou J., Xia Y., Su B., Liu T., Cui J., Sun Y., Lou H., Huang J. EMBO Rep. 14:1104-1112(2013)

2. "PrimPol, an archaic primase/polymerase operating in human cells." Garcia-Gomez S., Reyes A., Martinez-Jimenez M.I., Chocron E.S., Mouron S., Terrados G., Powell C., Salido E., Mendez J., Holt I.J., Blanco L. Mol. Cell 52:541-553(2013)

3. "PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication." Bianchi J., Rudd S.G., Jozwiakowski S.K., Bailey L.J., Soura V., Taylor E., Stevanovic I., Green A.J., Stracker T.H., Lindsay H.D., Doherty A.J. Mol. Cell 52:566-573(2013)

Sequence Similarity

Belongs to the eukaryotic-type primase small subunit family.

Subcellular Location

Nucleus

UNIPROT

SwissProt: Q96LW4 Human

Synonyms

CC111_HUMAN antibody

CCDC111 antibody

Coiled coil domain containing 111 antibody

Coiled-coil domain-containing protein 111 antibody

DNA-directed primase/polymerase protein antibody

MYP22 antibody

Primase and polymerase (DNA directed) antibody

PRIMPOL antibody