MAVS Rabbit Polyclonal Antibody
Catalog# ER1912-80
MAVS Rabbit Polyclonal Antibody
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WB
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Mouse
-
unconjugated
Overview
Product Name
MAVS Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
KLH conjugated synthetic peptide derived from human MAVS N terminus 3-100/540
Species Reactivity
Mouse
Validated Applications
WB
Molecular Weight
56 KDa
Positive Control
Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
Storage Instructions
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
WB
-
1:500-2000
Target
Function
Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis
Background References
暂无
Subcellular Location
Mitochondrion outer membrane.
UNIPROT
Synonyms
CARD adapter inducing interferon beta antibody
CARD adaptor inducing IFN beta antibody
Cardif antibody
DKFZp666M015 antibody
FLJ27482 antibody
FLJ41962 antibody
IFN B promoter stimulator 1 antibody
Interferon beta promoter stimulator protein 1 antibody
Ips 1 antibody
IPS-1 antibody
ExpandImages
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Sample:
Liver (Mouse) Lysate at 40 ug
Primary: Anti- MAVS (ER1912-80) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 56 kD
Observed band size: 56 kD
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Alternative Products
MAVS Recombinant Rabbit Monoclonal Antibody [PSH0-30]
Application: WB,IHC-P,IF-Cell,IP
Reactivity: Human,Mouse
Conjugate: unconjugated
MAVS Recombinant Rabbit Monoclonal Antibody [PSH01-65]
Application: WB,IHC-P,IF-Cell,IF-Tissue
Reactivity: Human
Conjugate: unconjugated
Products with the same target and pathway
MAVS Recombinant Rabbit Monoclonal Antibody [PSH0-30]
Application: WB,IHC-P,IF-Cell,IP
Reactivity: Human,Mouse
Conjugate: unconjugated
MAVS Recombinant Rabbit Monoclonal Antibody [PSH01-65]
Application: WB,IHC-P,IF-Cell,IF-Tissue
Reactivity: Human
Conjugate: unconjugated
