MUC2 Recombinant Rabbit Monoclonal Antibody
Catalog# IRS175RB
MUC2 Recombinant Rabbit Monoclonal Antibody
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mIHC
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Human
-
unconjugated
Overview
Product Name
MUC2 Recombinant Rabbit Monoclonal Antibody
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Synthetic peptide within Human MUC2 aa 5100-5149 / 5179.
Species Reactivity
Human
Validated Applications
mIHC
Molecular Weight
Predicted band size: 551 kDa
Positive Control
Human colon tissue.
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
mIHC
-
1:100
Target
Function
The mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs) encoded by 60 base pairs (Mucin 1), 69 base pairs (Mucin 2) and 51 base pairs (Mucin 3). The number of repeats is highly polymorphic and varies among different alleles. Mucin 1 proteins are expressed as type I membrane proteins in addition to secreted forms. Mucin 1 is aberrantly expressed in epithelial tumors including breast carcinomas. Mucin 2 coats the epithelia of the intestines and airways and is associated with colonic tumors. Mucin 3 is a major com-ponent of various mucus gels and is broadly expressed in normal and tumor cells.
Background References
1. Xiong J et al. Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice. Sci Rep 6:34079 (2016).
2. Hensel KO et al. Differential expression of mucosal trefoil factors and mucins in pediatric inflammatory bowel diseases. Sci Rep 4:7343 (2014).
Subcellular Location
Secreted.
UNIPROT
Synonyms
Intestinal mucin 2 antibody
Intestinal mucin-2 antibody
MLP antibody
MUC 2 antibody
MUC-2 antibody
Muc2 antibody
MUC2_HUMAN antibody
Mucin 2 antibody
Mucin 2 intestinal antibody
Mucin 2 intestinal/tracheal antibody
ExpandImages
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mIHC analysis of human colon tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-MUC2 antibody (IRS175RB) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Products with the same target and pathway
MUC2 Recombinant Rabbit Monoclonal Antibody [JA10-92] - BSA and Azide free
Application: WB,IF-Cell,IF-Tissue,IHC-P
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
