MuRF1 Mouse Monoclonal Antibody [B8-E1]

Function

Muscle specific RING finger protein (MuRF1) is a sarcomere-associated protein that is upregulated by conditions that provoke atrophy. Pharmacological or genetic inhibition of the IKKbeta/NF-kappaB/MuRF1 pathway reverses muscle atrophy, which presents MuRF as a target for clinical intervention. MuRF1 is a key regulator of the PKC-dependent hypertrophic response and can blunt cardiomyocyte hypertrophy, which may have important implications in the pathophysiology of clinical cardiac hypertrophy. MuRF1 directly associates with Titin kinase and influences microtubule-dependent signaling pathways in striated muscle and iris. MuRF1 upregulation is an indicator for skeletal muscle atrophy mechanisms that utilize ubiquitin-dependent proteolysis. MuRF1 transcript levels are high in situations where there is an overabundance of reactive oxygen species, such as cancer, AIDS and sepsis.

Background References

1. Pomiès P et al.Involvement of the FoxO1/MuRF1/Atrogin-1 Signaling Pathway in the Oxidative Stress-Induced Atrophy of Cultured Chronic Obstructive Pulmonary Disease Myotubes. PLoS One11:e0160092 (2016).

2. Li B et al. Baicalin, a component of Scutellaria baicalensis, alleviates anorexia and inhibits skeletal muscle atrophy in experimental cancer cachexia. Tumour Biol N/A:N/A (2014).

Subcellular Location

Cytoplasm. Nucleus

UNIPROT

SwissProt: Q969Q1 Human

Synonyms