Noggin Rabbit Polyclonal Antibody

Function

Noggin is a signaling molecule that plays an important role in promoting somite patterning in the developing embryo. It is released from the notochord and regulates bone morphogenic protein (BMP4) during development. The absence of BMP4 will cause the patterning of the neural tube and somites from the neural plate in the developing embryo. It also causes formation of the head and other dorsal structures. Noggin function is required for correct nervous system, somite, and skeletal development. Experiments in mice have shown that noggin also plays a role in learning, cognition, bone development, and neural tube fusion. Heterozygous missense mutations in the noggin gene can cause deformities such as joint fusions and syndromes such as multiple synostosis syndrome (SYNS1) and proximal symphalangism (SIM1). SYNS1 is different from SYM1 by causing hip and vertebral fusions. The embryo may also develop shorter bones, miss any skeletal elements, or lack multiple articulating joints. Increased plasma levels of Noggin have been observed in obese mice and in patients with a body mass index over 27. Additionally, it has been shown that Noggin depletion in adipose tissue leads to obesity.

Background References

1. Schwaerzer G K et al. New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance. J Bone Miner Res 27:429-442 (2012).

2. Wang J et al. A New Subtype of Multiple-Synostoses Syndrome is Caused by a Mutation in GDF6 that Decreases its Sensitivity to Noggin and Enhances its Potency as a BMP Signal. J Bone Miner Res 31:882-889 (2016).

Sequence Similarity

Belongs to the noggin family.

Subcellular Location

Secreted.

UNIPROT

SwissProt: Q13253 Human

SwissProt: P97466 Mouse

Synonyms

Nog antibody

NOGG_HUMAN antibody

Noggin antibody

SYM 1 antibody

SYM1 antibody

Symphalangism 1 (proximal) antibody

Synostoses (multiple) syndrome 1 antibody

SYNS 1 antibody

SYNS1 antibody