PER3 Mouse Monoclonal Antibody [9B-7D]

Function

Biological timepieces called circadian clocks are responsible for the regulation of hormonal rhythms, sleep cycles and other behaviors. The superchiasmatic nucleus (SCN), which is located in the brain, was the first mammalian circadian clock to be discovered. A number of transcription factors appearing to be molecular components of the SCN clock have been identified. Mutations within the Clock gene increase the length of the endogenous period and cause a loss of rhythmicity of circadian oscillations. Three mammalian period proteins, designated Per1, Per2 and Per3, exhibit circadian rhythyms in the SCN. During subjective night, Per1 and Per2 RNA levels increase in response to light pulses while Per3 RNA levels show no change in response to light pulses. Tim, for timeless, interacts with Per1 as well as Per2; and Tim and Per1 negatively regulate Clock-BMAL1-induced transcription.

Background References

1. Zhao B et al. A functional polymorphism in PER3 gene is associated with prognosis in hepatocellular carcinoma. Liver Int 32(9):1451-9 (2012).

2. Wang X et al. Reduced expression of PER3 is associated with incidence and development of colon cancer. Ann Surg Oncol 19(9):3081-8 (2012).

Subcellular Location

Cytoplasm, nucleus

UNIPROT

SwissProt: P56645 Human

Synonyms