PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-64] - BSA and Azide free

Function

Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF).

Background References

1. Moshkanbaryans L., Xue J., Wark J.R., Robinson P.J., Graham M.E. A Novel Sequence in AP180 and CALM Promotes Efficient Clathrin Binding and Assembly. PLoS ONE 11:E0162050-E0162050 (2016)

2. Sahlender D.A., Kozik P., Miller S.E., Peden A.A., Robinson M.S. Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation. PLoS ONE 8:E64514-E64514 (2013)

Subcellular Location

Cell membrane, Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus

UNIPROT

SwissProt: Q13492 Human

SwissProt: Q7M6Y3 Mouse

SwissProt: O55012 Rat

Synonyms

CALM antibody

Clathrin assembly lymphoid myeloid leukemia antibody

Clathrin assembly lymphoid myeloid leukemia protein antibody

CLTH antibody

LAP antibody

Phosphatidylinositol-binding clathrin assembly protein antibody

PICAL_HUMAN antibody

PICALM antibody