PSD95 Mouse Monoclonal Antibody [B5-E6]

Function

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Background References

1. Truncating variants of the DLG4 gene are responsible for intellectual disability with marfanoid features. Moutton S. et. al. Clin Genet. 2018 Jun

2. Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer\'s disease mice. Bustos FJ. et. al. Brain. 2017 Dec

Sequence Similarity

Belongs to the MAGUK family.

Tissue Specificity

Brain.

Post-translational Modification

Palmitoylated. Palmitoylation is required for targeting to postsynaptic density, plasma membrane and synapses (By similarity). Palmitoylation by ZDHHC2 occurs when the synaptic activity decreases and induces DLG4 synaptic clustering (By similarity). Palmitoylation may play a role in glutamate receptor GRIA1 synapse clustering (By similarity). Depalmitoylated by ABHD17A and ABHD17B and to a lesser extent by ABHD17C, ABHD12, ABHD13, LYPLA1 and LYPLA2. Undergoes rapid synaptic palmitoylation/depalmitoylation cycles during neuronal development which slow down in mature neurons (By similarity).; Ubiquitinated by MDM2 in response to NMDA receptor activation, leading to proteasome-mediated degradation of DLG4 which is required for AMPA receptor endocytosis.

Subcellular Location

Cell membrane, postsynaptic density, synapse, Cytoplasm, axon, dendritic spine, dendrite, presynapse.

UNIPROT

SwissProt: P78352 Human

SwissProt: Q62108 Mouse

SwissProt: P31016 Rat

Synonyms