Pan-Cadherin Recombinant Rabbit Monoclonal Antibody

Function

The cadherins are a large family of cell adhesion molecules involved in calcium-dependent recognition and adhesion events (1). Synaptic remodeling has been postulated as a mechanism underlying synaptic plasticity, and cadherin adhesion molecules are thought to be a regulator of such a process. Findings suggest that cadherin regulates dendritic spine morphogenesis and related synaptic functions, presumably cooperating with cadherin-independent adhesive mechanisms to maintain spine-axon contacts (2). Human retinoblastoma and normal retinal tissue the type of cadherin, its relationship with cytoplasmic catenins, and its participation in invasion has been examined. Retinoblastoma cells, in contrast with normal retina, express an cadherin-2/catenin complex that is irregularly distributed and weakly linked to the cytoskeleton. In retinoblastoma, this complex acts as an invasion promoter (3).

Background References

1. Wallis J, et al. Genomics 22(1):172-9, 1994.

2. Togashi H, et al. Neuron 35(1):77-89, 2002.

3. Van Aken EH, et al. Invest Ophthalmol Vis Sci 43(3): 595-602.

Subcellular Location

Cytoplasm, Cell junction

UNIPROT

SwissProt: P19022 Human

Synonyms