Phospho-p53 (S20) Recombinant Rabbit Monoclonal Antibody [PSH06-86]

Function

p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene. The TP53 gene is the most frequently mutated gene (>50%) in human cancer, indicating that the TP53 gene plays a crucial role in preventing cancer formation. TP53 gene encodes proteins that bind to DNA and regulate gene expression to prevent mutations of the genome. In addition to the full-length protein, the human TP53 gene encodes at least 12 protein isoforms.

Background References

1. Hassin O et al. Drugging p53 in cancer: one protein, many targets. Nat Rev Drug Discov. 2023 Feb

2. Hu J et al. Targeting mutant p53 for cancer therapy: direct and indirect strategies. J Hematol Oncol. 2021 Sep

Subcellular Location

Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, cytoskeleton, microtubule organizing center, centrosome.

UNIPROT

SwissProt: P04637 Human

Synonyms