IGF2R/M6PR Rabbit Polyclonal Antibody

Function

The mannose 6-phosphate/insulin-like growth factor II receptor, IGF-IIR (also designated M6P/IGF2R), is a ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGF∫1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore, IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers.

Background References

1. Munson MJ et al. mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival. EMBO J 34:2272-90 (2015).

2. Alsalem JA et al. Characterization of vitamin D production by human ocular barrier cells. Invest Ophthalmol Vis Sci 55:2140-7 (2014).

Sequence Similarity

Belongs to the MRL1/IGF2R family.

Subcellular Location

Golgi apparatus membrane, Endosome membrane.

UNIPROT

SwissProt: P11717 Human

Synonyms