RON Rabbit Polyclonal Antibody (R1512-2)

UNIPROT #

Q04912

PROTEIN NAME

RON

SYNONYMS

c met related tyrosine kinase antibody;CD136 antibody;CD136 antigen antibodyCDw136 antibody;Macrophage stimulating 1 receptor (c met related tyrosine kinase) antibody;Macrophage stimulating 1 receptor antibody;Macrophage stimulating protein receptor alpha chain antibody;MACROPHAGE STIMULATING PROTEIN RECEPTOR antibody;Macrophage stimulating protein receptor beta chain antibody;Macrophage-Stimulating 1 Receptor (MST1R) antibody;Macrophage-stimulating protein receptor beta chain antibody;MSP receptor antibody;Mst1r antibody;MST1R variant RON30 antibody;MST1R variant RON62 antibody;NPCA3 antibody;p185 RON antibody;p185-Ron antibody;Protein-tyrosine kinase 8 antibody;PTK 8 antibody;ptk8 antibody;PTK8 protein tyrosine kinase 8 antibody;Recepteur d’origine nantais (RON) antibody;RON antibody;RON protein tyrosine kinase antibody;RON variant E2E3 antibody;RON_HUMAN antibody;Soluble RON variant 1 antibody;Soluble RON variant 2 antibody;Soluble RON variant 3 antibody;Soluble RON variant 4 antibody;Stem cell derived tyrosine kinase antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.