Cytokeratin 13 Rabbit Polyclonal Antibody
Catalog# R1601-8
Cytokeratin 13 Rabbit Polyclonal Antibody
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WB
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IHC-P
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IF-Cell
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Human
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Mouse
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Rat
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unconjugated
Overview
Product Name
Cytokeratin 13 Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Recombinant protein within Human Cytokeratin 13 aa 71-319 / 458.
Species Reactivity
Human, Mouse, Rat
Validated Applications
WB, IHC-P, IF-Cell
Target Molecular Weight
45/49 kDa
Positive Control
Human skin tissue lysate, human tonsil tissue, mouse uterus tissue.
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
1 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
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WB
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1:500-1:2,000
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IHC-P
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1:50-1:200
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IF-Cell
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1:50-1:200
Target
Function
Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratins 10 and 13 are present in the cytoskeletal region of a subset of squamous cell carcinomas. Cytokeratin 13 belongs to the intermediate filament family and is a heterotetramer of two type I acidic and two type II basic keratins. It is generally associated with cytokeratin 4. Defects in the KRT13 gene are a cause of white sponge nevus of cannon (WSN), a rare autosomal dominant disorder which predominantly affects noncornified stratified squamous epithelia and is characterized by the presence of soft, white and spongy plaques in the oral mucosa.
Background References
1. Meng Q et al. Eyelid closure in embryogenesis is required for ocular adnexa development. Invest Ophthalmol Vis Sci 55:7652-61 (2014).
2. Fulzele A et al. Proteomic profile of keratins in cancer of the gingivo buccal complex: Consolidating insights for clinical applications. J Proteomics 91C:242-258 (2013).
Sequence Similarity
Belongs to the intermediate filament family.
Tissue Specificity
Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.
Post-translational Modification
O-glycosylated; glycans consist of single N-acetylglucosamine residues.
Subcellular Location
Cytoskeleton, Nucleus.
Synonyms
47 kDa cytokeratin antibody
CK-13 antibody
CK13 antibody
Cytokeratin 13 antibody
Cytokeratin-13 antibody
K13 antibody
K1C13_HUMAN antibody
Ka13 antibody
Keratin 13 antibody
Keratin antibody
ExpandImages
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Western blot analysis of Cytokeratin 13 on human skin tissue lysate using anti-Cytokeratin 13 antibody at 1/1,000 dilution.
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Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Cytokeratin 13 antibody. Counter stained with hematoxylin.
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Immunohistochemical analysis of paraffin-embedded mouse uterus tissue using anti-Cytokeratin 13 antibody. Counter stained with hematoxylin.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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