Hsp75 Recombinant Rabbit Monoclonal Antibody [SD08-71]

Function

The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multiprotein complexes, transportation of nascent polypeptide chains across cellular membranes and regulation of protein folding. Heat shock protein 75 mitochondrial precursor (HSP 75), also called tumor necrosis factor type 1 receptor-associated protein (TRAP1), is a 704 amino acid member of the heat shock protein 90 family. HSP 75 localizes to the mitochondrion and is expressed in a variety of tissues, including skeletal muscle, liver, heart, brain, pancreas, lung and placenta, functioning as a chaperone that expresses an ATPase activity.

Background References

1. Condelli, V. et al. 2015. Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: a novel strategy for human BRAF-driven colorectal carcinoma. Oncotarget. 6: 22298-309.

2. Campos-Martorell, M. et al. 2014. Brain proteomics identifies potential simvastatin targets in acute phase of stroke in a rat embolic model. Journal of neurochemistry. 130: 301-12.

Sequence Similarity

Belongs to the heat shock protein 90 family.

Tissue Specificity

Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.

Subcellular Location

Mitochondrion, Mitochondrion inner membrane, Mitochondrion matrix.

UNIPROT

SwissProt: Q12931 Human

Synonyms