SIRT5 Recombinant Rabbit Monoclonal Antibody [JJ084-01]

Function

SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.

Background References

1. Teng P et al. SIRT5-mediated ME2 desuccinylation promotes cancer growth by enhancing mitochondrial respiration. Cell Death Differ. 2024 Jan

2. Wu M et al. Sirt5 improves cardiomyocytes fatty acid metabolism and ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via CPT2 de-succinylation. Redox Biol. 2024 Jul

Sequence Similarity

Belongs to the sirtuin family. Class III subfamily.

Tissue Specificity

Widely expressed.

Subcellular Location

Mitochondrion matrix, Mitochondrion intermembrane space, Cytoplasm, cytosol, Nucleus.

UNIPROT

SwissProt: Q9NXA8 Human

SwissProt: Q8K2C6 Mouse

Synonyms