TWEAKR Recombinant Rabbit Monoclonal Antibody [SN20-07]
Catalog# ET1611-93
TWEAKR Recombinant Rabbit Monoclonal Antibody [SN20-07]
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WB
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IHC-P
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IP
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Human
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Mouse
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Rat
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unconjugated
Overview
Product Name
TWEAKR Recombinant Rabbit Monoclonal Antibody [SN20-07]
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Synthetic peptide within Human TWEAKR aa 80-129 / 129.
Species Reactivity
Human, Mouse, Rat
Validated Applications
WB, IHC-P, IP
Molecular Weight
14 kDa
Positive Control
NIH/3T3 cell lysates , C2C12 cell lysates, mouse uterus tissue.
Conjugation
unconjugated
Clone Number
SN20-07
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
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WB
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1:500-1:1,000
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IHC-P
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1:50-1:200
Target
Function
Fn14, the TWEAK receptor, is a recently identified member of the TNF receptor superfamily and is expressed on smooth muscle cells and endothelial cells. It is a weak inducer of apoptosis and promotes angiogenesis. Fn14 is a type 1 membrane protein. It associates with TRAF1 and TRAF2, and may modulate cellular adhesion to matrix proteins. Fn14 is highly expressed in heart, placenta and kidney, and moderately expressed in lung, skeletal muscle and pancreas. It is the smallest member of the TNF receptor (TNFR) superfamily described to date, and signals via recruitment of several different TNFR-associated factors.
Background References
1. Peng QL et al. Expression of tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 in patients with polymyositis and dermatomyositis. Arthritis Res Ther 16:R26 (2014).
2. Ameri H et al. TWEAK/Fn14 pathway is a novel mediator of retinal neovascularization. Invest Ophthalmol Vis Sci 55:801-13 (2014).
Tissue Specificity
Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.
Subcellular Location
Membrane.
Synonyms
CD 266 antibody
CD266 antibody
CD266 antigen antibody
FGF inducible 14 antibody
FGF-inducible 14 antibody
Fibroblast growth factor inducible immediate early response protein 14 antibody
Fibroblast growth factor-inducible immediate-early response protein 14 antibody
FN 14 antibody
FN14 antibody
TNFRSF 12A antibody
ExpandImages
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Western blot analysis of TWEAKR on different lysates using anti-TWEAKR antibody at 1/1,000 dilution.
Positive control:
Lane 1: NIH/3T3 cell lysates
Lane 2: C2C12 cell lysates -
Immunohistochemical analysis of paraffin-embedded mouse uterus tissue using anti-TWEAKR antibody. Counter stained with hematoxylin.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Citation
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Catalpol Research on the Mechanism of Antimyocardial Reperfusion Injury by Regulating the MiR-126/TWEAK-FN14 Pathway: In Vitro and Computer Simulation Studies
Journal: ACS Omega
DOI: 10.1021/acsomega.4c11357
IF: 3.7
Application: WB
Reactivity: Rat
Publish date: 2025 May
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Single-cell RNA sequencing and spatial transcriptomics of bladder Ewing sarcoma
Journal: iScience
DOI: 10.1016/j.isci.2024.110921
IF: 4.6
Application:
Reactivity:
Publish date: 2024 Sept
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The CD163/TWEAK/Fn14 axis: A potential therapeutic target for alleviating inflammatory bone loss
Journal: Journal Of Orthopaedic Translation
DOI:
IF: 5.9
Application: IHC-P
Reactivity: Mouse
Publish date: 2024 Oct
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