SARP3 Mouse Monoclonal Antibody [4G04]
Catalog# RT1557
SARP3 Mouse Monoclonal Antibody [4G04]
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WB
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IP
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IF
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Human
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Mouse
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Rat
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unconjugated
Overview
Product Name
SARP3 Mouse Monoclonal Antibody [4G04]
Antibody Type
Mouse Monoclonal Antibody
Immunogen
peptide
Species Reactivity
Human, Mouse, Rat
Validated Applications
WB, IP, IF
Molecular Weight
40kDa
Positive Control
293T
Conjugation
unconjugated
Clone Number
4G04
Product Features
Form
Liquid
Concentration
Storage Instructions
Store at +4℃
Storage Buffer
1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
Isotype
IgG1
Purification Method
Protein A affinity purified.
Application Dilution
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WB
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1:100-1:1,000
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IP
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1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
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IF
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1:50-1:500
Target
Function
The frizzled gene was originally identified in Drosophila melanogaster and was shown to be involved in the development of tissue polarity. The mammalian homolog of frizzled, as well as several mammalian frizzled-related proteins, FRP-1 (also designated SARP2), FRP-2 (also designated SARP1), FRP-3 and SARP3 (also designated FRP-5) have been identified. Frizzled is a transmem- brane protein that functions as a receptor for Wnt. The frizzled related proteins FRP-1, FRP-2, FRP-3 and SARP3 are secreted proteins that contain regions of homology to the cysteine-rich ligand-binding domain of frizzled. The FRPs/ SARPs have also been shown to be involved in the Wnt signaling pathway by regulating the intracellular levels of β-catenin.
Background References
1. Chang, J.T., et al. 1998. Cloning and characterization of a secreted friz- zled-related protein that is expressed by the retinal pigment epithelium. Hum. Mol. Genet. 8: 575-583.
2. Leimeister , C., et al. 1998. Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family. Mech. Dev. 75: 29-42.
Subcellular Location
Secreted
UNIPROT
Synonyms
Frizzled related protein 1b antibody
FRP 1b antibody
FRP1b antibody
SARP 3 antibody
SARP3 antibody
Secreted apoptosis related protein 3 antibody
Secreted frizzled related protein 5 antibody
SFRP 5 antibody
Images
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Western blot analysis of SARP3 expression in non-transfected (A) and human SARP3 transfected (B) 293T whole cell lysates.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"