SCF Mouse Monoclonal Antibody [4G5]

Function

Stem cell factor (SCF) is the ligand for the transmembrane tyrosine kinase receptor proto-oncogene c-Kit. SCF, also designated KL, MGF and SLF, is a pleiotropic cytokine that has two alternatively spliced forms, 248 and 220 amino acids in length in human and mouse systems, respectively. Both the larger form and the smaller form are cleaved to produce soluble forms. The smaller splice variant lacks the proteolytic cleavage site, between amino acids 149 and 177 of the larger SCF form. The larger SCF form is expressed in fibroblasts, brain and thymus, while the smaller SCF form is found in the spleen, testis, placenta and cerebellum. The SCF ligand is essential for the development of germ cells, hematopoietic progenitor cells and melanocyte precursors. With respect to mast cells, SCF can stimulate the proliferation of mature mast cells as well as the maturation and proliferation of immature mast cells

Background References

1. Krasagakis, K., et al. 2011. KIT receptor activation by autocrine and paracrine stem cell factor stimulates growth of merkel cell carcinoma in vitro. J. Cell. Physiol. 226: 1099-1109.

2. David, A., et al. 2011. Immunohistochemical localization of growth factors after cryopreservation and 3 weeks’ xenotransplantation of human ovarian tissue. Fertil. Steril. 95: 1241-1246.

Subcellular Location

Cytoplasm, Secreted, Cell membrane

UNIPROT

SwissProt: P21583 Human

Synonyms