SMAD6 Mouse Monoclonal Antibody [H6-H3]

Function

Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MADH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and activin-mediated growth modulation (2-5,8). Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad family members.

Background References

1. Ding Z Y et al. Smad6 suppresses the growth and self-renewal of hepatic progenitor cells. Journal of cellular physiology 229: 651-60 (2014).

2. Wang S et al. Up-regulation of BMP-2 antagonizes TGF-β1/ROCK-enhanced cardiac fibrotic signalling through activation of Smurf1/Smad6 complex. J Cell Mol Med 16: 2301-2310 (2012).

Subcellular Location

Nucleus.

UNIPROT

SwissProt: O43541 Human

Synonyms