STAT3 Rabbit Polyclonal Antibody

Function

Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF , induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expresion of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

Background References

1. Kaminski, K.A., et al. 2012. Interleukin 6 is not necessary for STAT3 phosphorylation and myocardial hypertrophy following short term β-adrenergic stimulation. Adv. Med. Sci. 57: 94-99

2. Zhang, W.N., et al. 2012. CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signal transducers and activators of transcription 3 signaling. J. Biol. Chem. 287: 382-392.

Subcellular Location

Cytoplasm, Nucleus

UNIPROT

SwissProt: P40763 Human

Synonyms