TGF beta 1 Mouse Monoclonal Antibody [B2-F6]
Catalog# EM1709-93
TGF beta 1 Mouse Monoclonal Antibody [B2-F6]
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WB
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IHC-P
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FC
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Human
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unconjugated
Overview
Product Name
TGF beta 1 Mouse Monoclonal Antibody [B2-F6]
Antibody Type
Mouse Monoclonal Antibody
Immunogen
Recombinant protein within human TGF beta 1 aa 62-195.
Species Reactivity
Human
Validated Applications
WB, IHC-P, FC
Molecular Weight
44 kDa
Positive Control
Human TGF beta 1 recombinant protein, human lung tissue, human lymphoid tissue, A549.
Conjugation
unconjugated
Clone Number
B2-F6
Product Features
Form
Liquid
Concentration
Storage Instructions
4℃; -20℃ for long term storage.
Storage Buffer
Purified antibody in PBS with 0.05% sodium azide.
Isotype
IgG1
Purification Method
Protein A affinity purified.
Application Dilution
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WB
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1:500-1:1,000
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IHC-P
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1:100-1:500
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FC
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1:100-1:200
Target
Function
The transforming growth factors b (TGFβ) superfamily is composed of numerous growth and differentiation factors, including TGFβ1-3. TGFβs are secreted from cells as latent complexes consisting of mature dimeric growth factor, the latency-associated propeptide (LAP) and a distinct gene product, latent TGFβ binding protein LTBP. Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis. The precursor of TGFβ is cleaved into mature TGFβ and LAP (latency associated peptide). Mature TGFβ remains associated with LAP by non-covalent interactions that block TGFβ from binding to its receptor.
Background References
暂无
Subcellular Location
Secreted. Extracellular matrix.
UNIPROT
Synonyms
Cartilage-inducing factor antibody
CED antibody
Differentiation inhibiting factor antibody
DPD1 antibody
LAP antibody
Latency-associated peptide antibody
Prepro transforming growth factor beta 1 antibody
TGF beta 1 antibody
TGF beta antibody
TGF beta 1 protein antibody
ExpandImages
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Western blot analysis of TGF beta 1 on human TGF beta 1 recombinant protein using anti- TGF beta 1 antibody at 1/1,000 dilution.
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Immunohistochemical analysis of paraffin-embedded human lung tissue using anti- TGF beta 1 antibody. Counter stained with hematoxylin.
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Immunohistochemical analysis of paraffin-embedded human lymphoid tissue using anti- TGF beta 1 antibody. Counter stained with hematoxylin.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Citation
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The Kinesin Eg5 Inhibitor K858 Enhances Radiosensitivity in Esophageal Squamous Cell Carcinoma and Affects the Expression of Epithelial-mesenchymal Transition Related Markers: In vitro and In vivo Studies
Journal: Anti-Cancer Agents In Medicinal Chemistry
DOI: 10.2174/0118715206373782250211104402
IF: 3
Application: WB
Reactivity: Human
Publish date: 2025 Feb
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Inhibition of keloid fibroblast proliferation by artesunate is mediated by targeting the IRE1α/XBP1 signaling pathway and decreasing TGF-β1
Journal: Burns
DOI:
IF: 2.7
Application: WB,IHC-P
Reactivity: Human
Publish date: 2024 Mar
-
DP7-C/mir-26a system promotes bone regeneration by remodeling the osteogenic immune microenvironment
Journal: Oral Diseases
DOI:
IF: 3.8
Application: WB
Reactivity: Rat
Publish date: 2024 Mar
-
Monocyte-derived immature dendritic cells negatively regulate hepatic stellate cells in vitro by secreting IL-10
Journal: Immunobiology
DOI:
IF:
Application: WB
Reactivity: Human
Publish date: 2023 Mar
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