Tet1 Rabbit Polyclonal Antibody

Function

TET1 (tet oncogene 1), also known as LCX or CXXC6, is a 2,136 amino acid protein that localizes to the nucleus and contains one CXXC-type zinc finger. Expressed in adult ovary, thymus and skeletal muscle and also present in fetal lung, heart and brain, TET1 is thought to play a role in the development of fetal organs and may also be involvement in the pathoegenesis and metastasis of acute myeloid leukemia (AML). The gene encoding TET1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

Background References

1. Takai H., et al. 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. Cell Rep. 9:48-60(2014).

2. Zhou H.,et al. Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. 12:260-271(2013)

Sequence Similarity

Belongs to the TET family.

Tissue Specificity

Expressed in fetal heart, lung and brain, and in adult skeletal muscle, thymus and ovary. Not detected in adult heart, lung or brain. Up-regulated in glioblastoma cells (at protein level).

Post-translational Modification

Glycosylated. Interaction with OGT leads to GlcNAcylation (By similarity).

Subcellular Location

Nucleus, Chromosome.

UNIPROT

SwissProt: Q8NFU7 Human

SwissProt: Q3URK3 Mouse

Synonyms