XBP1 Recombinant Rabbit Monoclonal Antibody [PSH23-23]

Function

X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. The XBP1 protein is a transcription factor that regulates the expression of genes important to the proper functioning of the immune system and in the cellular stress response. It was first identified by its ability to bind to the Xbox, a conserved transcriptional element in the promoter of the human leukocyte antigen (HLA) DR alpha. Abnormalities in XBP1 lead to a heightened ER stress and subsequently causes a heightened susceptibility for inflammatory processes that may contribute to Alzheimer's disease. In the colon, XBP1 anomalies have been linked to Crohn's disease.

Background References

1. Liu Z et al. XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury. Redox Biol. 2022 Jun

2. Wang Q et al. XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression. JHEP Rep. 2022 Aug

Subcellular Location

Nucleus, Cytoplasm, Endoplasmic reticulum membrane, Endoplasmic reticulum membrane, Membrane.

UNIPROT

SwissProt: P17861 Human

SwissProt: O35426 Mouse

SwissProt: Q9R1S4 Rat

Synonyms