ZFP-42/REX-1 Mouse Monoclonal Antibody [E7-B7-A7]

Function

REX-1/Zfp-42 was initially described as a factor present at high levels in murine F9 teratocarcinoma stem cells (EC).The Rex-1 (Zfp-42) gene encodes a zinc finger family transcription factor which is highly expressed in mouse and human embryonic stem cells. It is one of several gene markers used to identify human stem cells. REX-1 is found in spermatocytes and primary oocytes during replication and may play a role in meiosis. Recently, the expression of REX-1 in normal epithelial tissue cells has been demonstrated.

Background References

1. Mongan N.P., Martin K.M., Gudas L.J.; "The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures."; Mol. Carcinog. 45:887-900(2006).

2. Raman J.D., Mongan N.P., Liu L., Tickoo S.K., Nanus D.M., Scherr D.S., Gudas L.J.; "Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma."; Carcinogenesis 27:499-507(2006).

Sequence Similarity

Belongs to the krueppel C2H2-type zinc-finger protein family.

Tissue Specificity

Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines.

Post-translational Modification

Polyubiquitinated by RNF12, leading to proteasomal degradation.

Subcellular Location

Nucleus

UNIPROT

SwissProt: Q96MM3 Human

Synonyms