ZFX Rabbit Polyclonal Antibody

Function

The ZFX (X-linked zinc fnger protein) gene is expressed from the inactive X chromosome and is structurally similar to its homologue on the Y chromosome, ZFY. Transcripts of ZFX and ZFY encode proteins composed of a highly acidic amino-terminal domain and a carboxy-terminal zinc-fnger motif that is commonly associated with nucleic acid-binding proteins. Conditional gene targeting studies in mouse have suggested ZFX is also required for self-renewal of embryonic and hematopoietic stem cells. ZFX has also been suggested to play a role in proliferation and expansion of B cells, and could contribute to lymphocyte homeostasis.

Background References

1. Schneider-Gaedicke A et al. ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation. Cell 57:1247-1258 (1989).

2. Galan-Caridad, J.M. et al. (2007) Cell 129, 345-57.

3. Arenzana, T.L. et al. (2009) Blood 113, 5857-67.

Sequence Similarity

Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.

Subcellular Location

Cell nucleus

UNIPROT

SwissProt: P17010 Human

Synonyms

X-linked zinc finger protein antibody

zfx antibody

ZFX_HUMAN antibody

Zinc finger protein, X-linked antibody

Zinc Finger X Chromosomal Protein antibody

Zinc finger X-chromosomal protein antibody

ZNF926 antibody