ACCN2 Rabbit Polyclonal Antibody (ER1803-33)

UNIPROT #

P78348

PROTEIN NAME

ACCN2

SYNONYMS

ACCN2 antibody;ACCN2_HUMAN antibody;Acid sensing ion channel 1 antibody;Acid sensing ion channel 1a protein antibody;Acid sensing ion channel antibody;Acid-sensing ion channel 1 antibody;AI843610 antibody;Amiloride sensitive cation channel 2 neuronal antibody;Amiloride-sensitive cation channel 2 antibody;ASIC antibody;ASIC1 antibody;ASIC1A antibody;B530003N02Rik antibody;BNaC2 antibody;Brain sodium channel 2 antibody;Cation channel amiloride sensitive neuronal 2 antibody;hBNaC2 antibody;neuronal antibody

SEQUENCE SIMILARITIES

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily.

TISSUE SPECIFICITY

Expressed in most or all neurons.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation by PKA regulates interaction with PRKCABP and subcellular location. Phosphorylation by PKC may regulate the channel.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.Isoform 1 does not display proton-gated cation channel activity.