Adiponectin receptor protein 1 Recombinant Rabbit Monoclonal Antibody [SC69-04] (ET1610-86)

UNIPROT #

Q96A54

PROTEIN NAME

Adiponectin receptor protein 1

SYNONYMS

ACDCR1 antibody;ADIPO R1 antibody;Adiponectin receptor protein 1 antibody;ADIPOR 1 antibody;Adipor1 antibody;ADR1_HUMAN antibody;CGI 45 antibody;CGI 45 protein antibody;CGI-45 antibody;CGI45 antibody;CGI45 protein antibody;FLJ25385 antibody;FLJ42464 antibody;PAQR1 antibody;Progestin and adipoQ receptor family member I antibody;TESBP1A antibody

SEQUENCE SIMILARITIES

Belongs to the ADIPOR family.

TISSUE SPECIFICITY

Widely expressed. Highly expressed in heart and skeletal muscle. Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Adiponectin receptor 1 (AdipoR1) is a protein which in humans is encoded by the ADIPOR1 gene. It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR1. Similar to G protein-coupled receptors (GPCRs), AdipoR1 also possesses 7 transmembrane domains. However, AdipoR1 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins. The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.