Aldolase B Rabbit Polyclonal Antibody (ER1901-42)

UNIPROT #

P05062

PROTEIN NAME

Aldolase B

SYNONYMS

ALDB antibody;ALDO B antibody;ALDO2 antibody;ALDOB antibody;ALDOB_HUMAN antibody;Aldolase 2 antibody;Aldolase B antibody;Aldolase B fructose bisphosphate antibody;Aldolase2 antibody;AldolaseB antibody;EC 4.1.2.13 antibody;Fructose bisphosphate aldolase B antibody;Fructose-bisphosphate aldolase B antibody;Liver type aldolase antibody;Liver-type aldolase antibody;MS1077 antibody

SEQUENCE SIMILARITIES

Belongs to the class I fructose-bisphosphate aldolase family.

SUBCELLULAR LOCATION

Cytoplasm, Cytoskeleton.

FUNCTION

Aldolase B also known as fructose-bisphosphate aldolase B or liver-type aldolase is one of three isoenzymes (A, B, and C) of the class I fructose 1,6-bisphosphate aldolase enzyme (EC 4.1.2.13), and plays a key role in both glycolysis and gluconeogenesis. The generic fructose 1,6-bisphosphate aldolase enzyme catalyzes the reversible cleavage of fructose 1,6-bisphosphate (FBP) into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (DHAP) as well as the reversible cleavage of fructose 1-phosphate (F1P) into glyceraldehyde and dihydroxyacetone phosphate. In mammals, aldolase B is preferentially expressed in the liver, while aldolase A is expressed in muscle and erythrocytes and aldolase C is expressed in the brain. Slight differences in isozyme structure result in different activities for the two substrate molecules: FBP and fructose 1-phosphate. Aldolase B exhibits no preference and thus catalyzes both reactions, while aldolases A and C prefer FBP. In humans, aldolase B is encoded by the ALDOB gene located on chromosome 9. The gene is 14,500 base pairs long and contains 9 exons. Defects in this gene have been identified as the cause of hereditary fructose intolerance (HFI).