Alpha B Crystallin Recombinant Rabbit Monoclonal Antibody [JA50-32] (ET1704-60)

UNIPROT #

P02511

PROTEIN NAME

Alpha B Crystallin

SYNONYMS

AACRYA antibody;Alpha B crystallin antibody;Alpha crystallin B chain antibody;Alpha(B)-crystallin antibody;Alpha-crystallin B chain antibody;CRYA2 antibody;Cryab antibody;CRYAB_HUMAN antibody;Crystallin alpha B antibody;Crystallin alpha polypeptide 2 antibody;CTPP2 antibody;Heat shock 20 kD like protein antibody;Heat shock protein beta 5 antibody;Heat shock protein beta-5 antibody;HspB5 antibody;Renal carcinoma antigen NY REN 27 antibody;Renal carcinoma antigen NY-REN-27 antibody;Rosenthal fiber component antibody

SEQUENCE SIMILARITIES

Belongs to the small heat shock protein (HSP20) family.

TISSUE SPECIFICITY

Lens as well as other tissues. Expressed in myocardial tissue.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into α, β and γ families, and the β- and γ-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, inclu-ding four homologous motifs, a connecting peptide, and N- and C-terminal extensions. α-crystallins consist of three gene products, αA-, αB- and αC-crystallin, which are members of the small heat shock protein family (HSP 20). α-crystallins act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, α-crystallins do not renature these proteins. Expression of αA-crystallin is restricted to the lens and defects of this gene cause the development of autosomal dominant congenital cataracts (ADCC). The human αB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of αB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.