alpha Internexin Recombinant Rabbit Monoclonal Antibody [JU25-03] (ET1706-23)

UNIPROT #

Q16352

PROTEIN NAME

alpha Internexin

SYNONYMS

66 kDa neurofilament protein antibody;AINX_HUMAN antibody;Alpha Inx antibody;Alpha-internexin antibody;Alpha-Inx antibody;INA antibody;Internexin neuronal intermediate filament protein alpha antibody;MGC12702 antibody;NEF 5 antibody;NEF5 antibody;Neurofilament 5 (66kD) antibody;Neurofilament 5 antibody;Neurofilament 66 antibody;Neurofilament 66 tax binding protein antibody;Neurofilament-66 antibody;NF 66 antibody;NF-66 antibody;NF66 antibody;TXBP 1 antibody;TXBP1 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

TISSUE SPECIFICITY

Found predominantly in adult CNS.

DEVELOPMENTAL STAGE

Expressed in brain as early as the 16th week of gestation, and increased rapidly and reached a steady state level by the 18th week of gestation.

POST-TRANSLATIONAL MODIFICATION

O-glycosylated.

SUBCELLULAR LOCATION

Intermediate filament cytoskeleton, neurofilament, extracellular space, cytoplasmic ribonucleoprotein granule, postsynapse, Schaffer collateral - CA1 synapse.

FUNCTION

Alpha-internexin is a brain specific type IV intermediate filament protein. This axonal protein is found in most, if not all, neurons of the CNS. The head domain of alpha-internexin is essential for self-assembly into a filament network. Expression levels of alpha-internexin have been shown to be maximal during late embryogenesis and to decline into adulthood, suggesting that this protein plays a role in regulatory processes during the development of the brain. The alpha-internexin promoter has been shown to be activated by Brn-3a or Brn-3c transcription factor binding, while Brn-3b binding to the promoter results in alpha-internexin repression.