APC6 Recombinant Rabbit Monoclonal Antibody [SD085-8] (ET1612-86)

UNIPROT #

Q13042

PROTEIN NAME

APC6

SYNONYMS

ANAPC6 antibody;Anaphase promoting complex subunit 6 antibody;Anaphase-promoting complex subunit 6 antibody;Apc 6 antibody;APC6 antibody;CDC 16 antibody;CDC16 (cell division cycle 16 S. cerevisiae homolog) antibody;Cdc16 antibody;CDC16 homolog antibody;CDC16 protein antibody;CDC16_HUMAN antibody;CDC16Hs antibody;Cell division cycle 16 antibody;Cell division cycle 16 homolog antibody;Cell division cycle protein 16 homolog antibody;CUT9 antibody;Cyclosome subunit 6 antibody

SEQUENCE SIMILARITIES

Belongs to the APC6/CDC16 family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division cycle (Cdc) genes are required at various points in the cell cycle. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4/cyclin D1 complex formation and has been shown to form a stable complex with Hsp90. Cdc34, Cdc27 and Cdc16 function as ubiquitin-conjugating enzymes. Cdc34 is thought to be the structural and functional homolog of Saccharomyces cerevisiae Cdc34, which is essential for the G1 to S phase transition. Cdc16 and Cdc27 are components of the APC (anaphase-promoting complex) which ubiquitinates cyclin B, resulting in cyclin B/Cdk complex degradation.