ATF2 Recombinant Rabbit Monoclonal Antibody [SZ17-01] (ET1603-15)

UNIPROT #

P15336

PROTEIN NAME

ATF2

SYNONYMS

Activating transcription factor 2 antibody;Activating transcription factor 2 splice variant ATF2 var2 antibody;ATF 2 antibody;Atf-2 antibody;Atf2 antibody;ATF2 protein antibody;ATF2_HUMAN antibody;cAMP Response Element Binding Protein 2 antibody;cAMP response element binding protein CRE BP1 antibody;cAMP response element-binding protein CRE-BP1 antibody;cAMP responsive element binding protein 2, formerly antibody;cAMP-dependent transcription factor ATF-2 antibody;cAMP-responsive element-binding protein 2 antibody;CRE BP1 antibody;CRE-BP antibody;CREB 2 antibody;CREB-2 antibody;CREB2 antibody;CREBP1 antibody;Cyclic AMP dependent transcription factor ATF 2 antibody;Cyclic AMP-dependent transcription factor ATF-2 antibody;Cyclic AMP-responsive element-binding protein 2 antibody;D130078H02Rik antibody;D18875 antibody;HB 16 antibody;HB16 antibody;Histone acetyltransferase ATF2 antibody;MGC105211 antibody;MGC105222 antibody;MGC111558 antibody;MGC142504 antibody;mXBP antibody;MXBP protein antibody;Tg(Gzma-Klra1)7Wum antibody;TREB 7 antibody;TREB7 antibody

SEQUENCE SIMILARITIES

Belongs to the bZIP family. ATF subfamily.

TISSUE SPECIFICITY

Ubiquitously expressed, with more abundant expression in the brain.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation of Thr-69 by MAPK14 and MAPK11, and at Thr-71 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in response to external stimulus like insulin causes increased transcriptional activity. Phosphorylated by PLK3 following hyperosmotic stress. Also phosphorylated and activated by JNK and CaMK4. ATM-mediated phosphorylation at Ser-490 and Ser-498 stimulates its function in DNA damage response. Phosphorylation at Ser-62, Thr-73 and Ser-121 activates its transcriptional activity. Phosphorylation at Thr-69 or Thr-71 enhances its histone acetyltransferase (HAT) activity.

SUBCELLULAR LOCATION

Nucleus, Membrane, Cytoplasm, Mitochondrion, Mitochondrion outer membrane.

FUNCTION

Eukaryotic gene transcription is regulated by sequence-specific transcription factors which bind modular cis-acting promotor and enhancer elements. The ATF/CREB transcription factor family binds the palindromic cAMP response element (CRE) octanucleotide TGACGTCA. The ATF/CREB family includes CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3. This family of proteins contain highly divergent N-terminal domains, but share a C-terminal leucine zipper for dimerization and DNA binding. ATF-2 forms homodimers and heterodimers with c-Jun to initiate CRE-dependent transcription. Phosphorylation of ATF-2 at Thr 69 and Thr 71 by stress-activated kinases is necessary for transcriptional activation. Myc also induces phosphorylation of ATF-2 at Thr 69 and Thr 71 to prolong the half-life of ATF-2. ATF-2 also functions as a histone acetyltransferase (HAT) by specifically acetylating histones H2B and H4 in vitro. The gene encoding human ATF-2 maps to chromosome 2q31.1.