Bag3 Recombinant Rabbit Monoclonal Antibody [JA90-53] (ET1704-73)

UNIPROT #

O95817

PROTEIN NAME

Bag3

SYNONYMS

BAG 3 antibody;BAG family molecular chaperone regulator 3 antibody;BAG-3 antibody;Bag3 antibody;BAG3_HUMAN antibody;Bcl 2 binding protein antibody;Bcl-2-associated athanogene 3 antibody;Bcl-2-binding protein Bis antibody;BCL2 associated athanogene 3 antibody;BCL2 binding athanogene 3 antibody;BIS antibody;CAIR 1 antibody;Docking protein CAIR 1 antibody;Docking protein CAIR-1 antibody;MFM6 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

The Bag family of proteins are characterized by the presence of a 45 amino acid Bag domain through which they bind with high affinity to the ATPase domain of HSP 70, thereby negatively regulating HSP 70 chaperone activity. Bag-3 (Bcl-2-associated athanogene 3), also known as BIS or CAIR-1, is a 575 amino acid protein that contains one C-terminal Bag domain and two N-terminal WW domains. Like other members of the Bag family, Bag-3 functions to inhibit the chaperone activity of HSP 70, specifically by promoting the release of HSP 70-bound substrates. Additionally, Bag-3 exhibits anti-apoptotic activity via cell cycle control, suggesting a possible role for Bag-3 in tumor progression. The gene encoding Bag-3 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.