beta Amyloid Recombinant Rabbit Monoclonal Antibody [PSH08-18]

Function

Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor and has been implicated as a regulator of synapse formation, neural plasticity, antimicrobial activity, and iron export. It is coded for by the gene APP and regulated by substrate presentation. APP is best known as the precursor molecule whose proteolysis generates amyloid beta (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients.

Background References

1. Ono K et al. Aggregation and structure of amyloid beta-protein. Neurochem Int. 2021 Dec

2. Yagi-Utsumi M et al. Conformational Variability of Amyloid-beta and the Morphological Diversity of Its Aggregates. Molecules. 2022 Jul

Subcellular Location

Cell membrane, Membrane, Perikaryon, Cell projection, growth cone, Membrane, clathrin-coated pit, Early endosome, Cytoplasmic vesicle.

UNIPROT

SwissProt: P05067 Human

SwissProt: P12023 Mouse

Synonyms