CACNG2 Rabbit Polyclonal Antibody (ER1901-89)

UNIPROT #

Q9Y698

PROTEIN NAME

CACNG2

SYNONYMS

AW060990 antibody;B230105C07Rik antibody;B930041E13Rik antibody;Cacng2 antibody;Calcium channel voltage dependent gamma subunit 2 antibody;CaV gamma 2 antibody;CCG2_HUMAN antibody;Ipr328 antibody;MGC123981 antibody;MGC138502 antibody;MGC138504 antibody;Neuronal voltage gated calcium channel gamma 2 subunit antibody;Neuronal voltage-gated calcium channel gamma-2 subunit antibody;Stargazer antibody;stg antibody;TARP gamma-2 antibody;Transmembrane AMPAR regulatory protein gamma-2 antibody;Voltage dependent calcium channel gamma 2 subunit antibody;Voltage-dependent calcium channel gamma-2 subunit antibody;Wag antibody;Waggler antibody

SEQUENCE SIMILARITIES

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

TISSUE SPECIFICITY

Brain.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation of Thr-321 impairs interaction with DLG1 and DLG4.

SUBCELLULAR LOCATION

Cell junction, Membrane.

FUNCTION

Calcium channel, voltage-dependent, gamma subunit 2, also known as CACNG2 or stargazin is a protein that in humans is encoded by the CACNG2 gene. L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This protein is similar to the mouse stargazin protein, mutations in which having been associated with absence seizures, also known as petit-mal or spike-wave seizures. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family. Stargazin is involved in the transportation of AMPA receptors to the synaptic membrane, and the regulation of their receptor rate constants — via its extracellular domain — once it is there. As it is highly expressed throughout the cerebral cortex, it is likely to have an important role in learning within these areas, due to the importance of AMPA receptors in LTP.