CaMKII delta Recombinant Rabbit Monoclonal Antibody [JA30-07] (ET1704-37)

UNIPROT #

Q13557

PROTEIN NAME

CaMKII delta

SYNONYMS

Calcium / calmodulin dependent protein kinase 2 delta antibody;Calcium / calmodulin dependent protein kinase II delta antibody;calcium/calmodulin-dependent protein kinase (CaM kinase) II delta antibody;calcium/calmodulin-dependent protein kinase type II delta chain antibody;Calcium/calmodulin-dependent protein kinase type II subunit delta antibody;CAM kinase 2 delta antibody;CAM kinase II delta antibody;CaM kinase II delta subunit antibody;CaM kinase II subunit delta antibody;CaM-kinase II delta chain antibody;CAMK 2d antibody;CaMK-II delta subunit antibody;CaMK-II subunit delta antibody;CAMK2D antibody;CAMKD antibody;CAMKI antibody;KCC2D_HUMAN antibody;RATCAMKI antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

TISSUE SPECIFICITY

Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle.

POST-TRANSLATIONAL MODIFICATION

Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.

SUBCELLULAR LOCATION

Sarcolemma. Sarcoplasmic reticulum membrane.

FUNCTION

Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca2homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca2influx into the myocyte, Ca2release from the sarcoplasmic reticulum (SR), SR Ca2uptake and Naand Kchannel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Regulates Ca2influx to myocytes by binding and phosphorylating the L-type Ca2channel subunit beta-2 CACNB2. In addition to Ca2channels, can target and regulate the cardiac sarcolemmal Nachannel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca2uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis.