Caspase-14 Recombinant Rabbit Monoclonal Antibody [JJ089-01] (ET1701-52)

UNIPROT #

P31944

PROTEIN NAME

Caspase-14

SYNONYMS

Caspase14;Apoptosis related cysteine protease antibody;CASP 14 antibody;CASP-14 antibody;CASP14 antibody;Caspase 14 apoptosis related cysteine protease antibody;Caspase 14 precursor antibody;Caspase-14 subunit p10 antibody;Caspase14 antibody;CASPE_HUMAN antibody;MGC119078 antibody;MGC119079 antibody;MICE antibody;Mini ICE antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C14A family.

TISSUE SPECIFICITY

Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels. The p17/10 mature form is expressed in epidermis stratum corneum, the p20/p8 intermediate form in epidermis upper granular cells of the stratum granulosum.

POST-TRANSLATIONAL MODIFICATION

Maturation by proteolytic processing appears to be a two-step process. The precursor is processed by KLK7 to yield the p20/p8 intermediate form which acts on the precursor to yield the p17/p10 mature form. Initially, cleavage between Ile-152 and Lys-153 has been proposed to yield the large and small subunits of the active enzyme.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is composed of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6 and caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9, caspase-10, and caspase-14. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-14, also designated MICE (for mini-ICE), is highly expressed in embryonic tissues but appears to be absent from adult tissues. Procaspase-14 can be processed in vitro by caspase-8 and caspase-10 but not by other caspases.