CD130 Mouse Monoclonal Antibody [B11-B9-A8] (EM1701-43)

UNIPROT #

P40189

PROTEIN NAME

CD130

SYNONYMS

CD130 antibody;CD130 antigen antibody;CDw130 antibody;gp130 antibody;GP130 RAPS antibody;IL 6R beta antibody;IL-6 receptor subunit beta antibody;IL-6R subunit beta antibody;IL-6R-beta antibody;IL-6RB antibody;IL6 ST antibody;IL6RB_HUMAN antibody;IL6ST antibody;Interleukin 6 receptor subunit beta antibody;Interleukin receptor beta chain antibody;Interleukin-6 receptor subunit beta antibody;Interleukin-6 signal transducer antibody;Membrane glycoprotein 130 antibody;Membrane glycoprotein gp130 antibody;Oncostatin M receptor antibody;Oncostatin M receptor alpha subunit antibody;Oncostatin-M receptor subunit alpha antibody

SEQUENCE SIMILARITIES

Belongs to the type I cytokine receptor family. Type 2 subfamily.

TISSUE SPECIFICITY

Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells. Expressed in blood serum (at protein level).

POST-TRANSLATIONAL MODIFICATION

Phosphorylation of Ser-782 down-regulates cell surface expression.; Heavily N-glycosylated. Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Glycoprotein 130 (also known as gp130, IL6ST, IL6R-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion.