CD24 Rabbit Polyclonal Antibody (0804-4)

UNIPROT #

P25063

PROTEIN NAME

CD24

SYNONYMS

CD 24 antibody;CD24 antibody;CD24 antigen (small cell lung carcinoma cluster 4 antigen) antibody;CD24 antigen antibody;CD24 molecule antibody;CD24_HUMAN antibody;CD24A antibody;FLJ22950 antibody;FLJ43543 antibody;GPI linked surface mucin antibody;Heat stable antigen antibody;HSA antibody;MGC75043 antibody;Nectadrin antibody;Signal transducer CD24 antibody;Small cell lung carcinoma cluster 4 antigen antibody

SEQUENCE SIMILARITIES

Belongs to the CD24 family.

TISSUE SPECIFICITY

B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.

POST-TRANSLATIONAL MODIFICATION

Extensively O-glycosylated.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

The human CD24 antigen is a small heavily glycosylated, glycosylphosphatidylinositol (GPI) linked cell surface protein. It consists of a small protein core comprising 27 amino acids, which is extensively glycosylated and is bound to the membrane via a phosphatidylinositol anchor. The human CD24 antigen is physiologically expressed in developing or regenerating tissue, as well as in granulocytes, keratinocytes and renal tubular epithelium. It modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor