CD44 Recombinant Rabbit Monoclonal Antibody [ST57-03] (ET1609-74)

UNIPROT #

P16070

PROTEIN NAME

CD44

SYNONYMS

LHR antibody;BA-1 antibody;CD 44 antibody;CD44 antibody;CD44 antigen antibody;CD44 molecule (Indian blood group) antibody;CD44 molecule antibody;CD44_HUMAN antibody;CDw44 antibody;Cell surface glycoprotein CD44 antibody;chondroitin sulfate proteoglycan 8 antibody;CSPG8 antibody;ECMR-III antibody;Epican antibody;Extracellular matrix receptor III antibody;GP90 lymphocyte homing/adhesion receptor antibody;HCELL antibody;hematopoietic cell E- and L-selectin ligand antibody;Heparan sulfate proteoglycan antibody;Hermes antigen antibody;homing function and Indian blood group system antibody;HSA antibody;HUTCH-I antibody;HUTCH1 antibody;Hyaluronate receptor antibody;IN antibody;MC56 antibody;MDU2 antibody;MDU3 antibody;MGC10468 antibody;MIC4 antibody;MUTCH1 antibody;PGP-1 antibody;PGP-I antibody;PGP1 antibody;Phagocytic glycoprotein 1 antibody;Phagocytic glycoprotein I antibody;Soluble CD44 antibody

TISSUE SPECIFICITY

Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

DEVELOPMENTAL STAGE

Expressed in the developing retina between 16 and 19 weeks post-conception, specifically in the outer neuroblastic zone, inner neuroblastic zone, interphotoreceptor zone and the retinal pigment epithelium (at protein level).

POST-TRANSLATIONAL MODIFICATION

Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.; N-glycosylated.; O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.; Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Cell adhesion molecules (CAMs) are a family of closely related, cell surface glycoproteins that are involved in cell-cell interactions and are thought to play an important role in embryogenesis and development. HCAM, also known as CD44, LHR, MDU2, MDU3, MIC4, Pgp1, HCELL, MUTCH-I or ECMR-III, is a 742 amino acid single-pass type I membrane protein that is involved in hematopoiesis, lymphocyte activation and tumor metastasis. Functioning as a receptor for hyaluronic acid (HA) and interacting with ligands such as osteopontin (OPN), HCAM mediates both cell-cell and cell-matrix interactions, thereby playing an essential role in cell adhesion and cell migration. HCAM contains one Link domain and, due to alternative splicing events, is expressed as multiple isoforms, some of which are designated CD44R, CDw44, CD44S, CD44H (hematopoietic) and CD44E (epithelial). While most of the HCAM splice varients are expressed in tissues throughout the body, one specific isoform, namely CD44H, is expressed at high levels in cancer tissue, suggesting an important role for the CD44H splice varient in tumor progression.