CD64 Mouse Monoclonal Antibody [A7E4] (HA601003)

UNIPROT #

P12314

PROTEIN NAME

CD64

SYNONYMS

CD 64 antibody;CD64 antibody;CD64 antigen antibody;CD64A antibody;CD64b antibody;CD64c antibody;Fc fragment of IgG high affinity Ia receptor antibody;Fc fragment of IgG high affinity Ib receptor antibody;Fc fragment of IgG high affinity Ic receptor antibody;Fc fragment of IgG, high affinity Ia, receptor (CD64) antibody;Fc fragment of IgG, high affinity Ia, receptor for (CD64) antibody;Fc fragment of IgG, high affinity Ia, receptor for antibody;Fc fragment of IgG, high affinity Ib, receptor (CD64) antibody;Fc fragment of IgG, high affinity Ib, receptor for antibody;Fc fragment of IgG, high affinity Ic, receptor (CD64) antibody;Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene antibody;Fc fragment of IgG, high affinity Ic, receptor for antibody;Fc gamma receptor antibody;Fc gamma receptor I A1 antibody;Fc gamma receptor I antibody;Fc gamma receptor I B2 antibody;Fc gamma RI antibody;Fc gamma RIA antibody;Fc gamma RIB antibody;Fc of IgG high affinity Ia receptor antibody;Fc-gamma RI antibody;Fc-gamma RIA antibody;Fc-gamma RIC antibody;FCG 1 antibody;FCG1 antibody;FcgammaRI antibody;FcgammaRIa antibody;FCGR 1 antibody;FCGR1 antibody;FCGR1_HUMAN antibody;FCGR1A antibody;FCGR1B antibody;FCGR1C antibody;FcRI antibody;FcRIB antibody;FCRIC antibody;FLJ18345 antibody;HFcgammaRIB antibody;High affinity immunoglobulin gamma Fc receptor I antibody;High affinity immunoglobulin gamma Fc receptor IB antibody;IGFR 1 antibody;IGFR1 antibody;IGFRB antibody;IGFRC antibody;IgG Fc receptor I antibody;IgG Fc receptor IB antibody;IgG Fc receptor IC antibody;Immunoglobulin G Fc receptor I antibody;Immunoglobulin G Fc receptor IB antibody;Immunoglobulin G Fc receptor IC antibody;MGC137713 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

CD64 (Cluster of Differentiation 64) is a type of integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity. It is more commonly known as Fc-gamma receptor 1 (FcγRI). After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation. Structurally CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail.CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells. There are three distinct (but highly similar) genes in humans for CD64 called FcγRIA (CD64A), FcγRIB (CD64B), and FcγRIC (CD64C) that are located on chromosome 1. These three genes produce six different mRNA transcripts; two from CD64A, three from CD64B, and one from CD64C; by alternate splicing of the genes.