CEBP alpha Recombinant Rabbit Monoclonal Antibody [SD202-09] (ET1612-46)

UNIPROT #

P49715

PROTEIN NAME

CEBP alpha

SYNONYMS

Apoptotic cysteine protease antibody;Apoptotic protease Mch 5 antibody;C/EBP alpha antibody;C/ebpalpha antibody;CAP4 antibody;Caspase 8 precursor antibody;CBF-A antibody;CCAAT Enhancer Binding Protein alpha antibody;CCAAT/enhancer binding protein (C/EBP), alpha antibody;CCAAT/enhancer-binding protein alpha antibody;CEBP antibody;CEBP A antibody;CEBP alpha antibody;Cebpa antibody;CEBPA_HUMAN antibody;FADD homologous ICE/CED 3 like protease antibody;FADD like ICE antibody;FLICE antibody;ICE like apoptotic protease 5 antibody;ICE8 antibody;MACH antibody;MCH5 antibody;MORT1 associated CED 3 homolog antibody

SEQUENCE SIMILARITIES

Belongs to the bZIP family. C/EBP subfamily.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-190 is required for interaction with CDK2, CDK4 and SWI/SNF complex leading to cell cycle inhibition. Dephosphorylated at Ser-190 by protein phosphatase 2A (PP2A) through PI3K/AKT signaling pathway regulation. Phosphorylation at Thr-226 and Thr-230 by GSK3 is constitutive in adipose tissue and lung. In liver, both Thr-226 and Thr-230 are phosphorylated only during feeding but not during fasting. Phosphorylation of the GSK3 consensus sites selectively decreases transactivation activity on IRE-controlled promoters.; Sumoylated, sumoylation blocks the inhibitory effect on cell proliferation by disrupting the interaction with SMARCA2.; Ubiquitinated by COP1 upon interaction with TRIB1.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The transcription factor C/EBP α (CCAAT-enhancer binding protein) is a heat-stable, sequence-specific DNA-binding protein that binds avidly to several different cis-regulatory DNA sequences commonly associated with viral and cellular genes transcribed by RNA polymerase II. C/EBP α regulates gene expression in a variety of tissues including liver, adipose, lung and intestine. C/EBP α is a basic region/leucine zipper transcription factor selectively expressed during the differentiation of liver, adipose tissue, blood cells and the endocrine pancreas. C/EBP α uses a bipartite structural motif to bind DNA and appears to function exclusively in terminally differentiated, growth-arrested cells. In the liver, C/EBP α is a transactivator of several genes, which are regulated by growth hormone. Growth hormone enhances not only the levels of C/EBP α mRNA and protein, but also the DNA binding activity of C/EBP α. C/EBP α functions as an important transcription factor that regulates different genes, including prolactin gene expression.