CELF2 Mouse Monoclonal Antibody [9B1] (EM1902-43)

UNIPROT #

O95319

PROTEIN NAME

CELF2

SYNONYMS

Bruno-like protein 3 antibody;BRUNOL3 antibody;Cardiac elav type RNA binding protein antibody;CELF-2 antibody;celf2 antibody;CELF2_HUMAN antibody;CUG BP2 antibody;CUG triplet repeat RNA-binding protein 2 antibody;CUG-BP- and ETR-3-like factor 2 antibody;CUG-BP2 antibody;CUGBP Elav like family member 2 antibody;CUGBP Elav-like family member 2 antibody;CUGBP2 antibody;dJ323N1.1 antibody;elav type RNA binding protein antibody;ELAV-type RNA-binding protein 3 antibody;ETR 3 antibody;ETR-3 antibody;ETR3 antibody;HGNC:2550 antibody;hNAPOR antibody;NAPOR 2 antibody;NAPOR antibody;Neuroblastoma apoptosis-related RNA-binding protein antibody;Neuroplastoma apoptosis related RNA binding protein 3 antibody;RNA binding protein BRUNOL3 antibody;RNA-binding protein BRUNOL-3 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5.