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Claudin18 Rabbit Polyclonal Antibody (HA500131)

Price: Regular price $315.00

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Catalog# HA500131

Rabbit Polyclonal to Claudin18

Tested for

  • WB

  • IHC-P

Reacts with

  • Human

Specifications

Product Type

Rabbit polyclonal primary

Product Name

Claudin18 Rabbit Polyclonal Antibody (HA500131)

Immunogen

Synthetic peptide within c-terminal human claudin18.

Host

Rabbit

Positive Control

293T cell lysates, human gastric carcinoma tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071229

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IHC-P:1:100-1:500

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

28 kDa

Isotype

IgG

TARGET

UNIPROT #

P56856

PROTEIN NAME

Claudin18

SYNONYMS

Claudin 18 antibody;Claudin-18 antibody;CLD18_HUMAN antibody;CLDN18 antibody;SFTA5 antibody;SFTPJ antibody

SUBCELLULAR LOCATION

Cell membrane, tight junction.

FUNCTION

Claudin-18 is a tight junction protein expressed as lung-and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene. The lung-specific form is a downstream target gene regulated by the T/EBP/NKX2.1 transcription factor. A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human. Human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein. Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in the cell-cell borders of these cells. These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach. Claudin-18 expression has also been reported in the inner ear.

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