Claudin 7 Mouse Monoclonal Antibody [6-G3] (M1412-2)

UNIPROT #

O95471

PROTEIN NAME

Claudin 7

SYNONYMS

CEPTR L2 antibody;CEPTRL 2 antibody;CEPTRL2 antibody;Claudin 1 antibody;Claudin 9 antibody;Claudin-7 antibody;Claudin1 antibody;Claudin7 antibody;Claudin9 antibody;CLD7_HUMAN antibody;CLDN 7 antibody;CLDN-7 antibody;CLDN7 antibody;Clostridium perfringens enterotoxin receptor like 2 antibody;CPETR L2 antibody;CPETRL 2 antibody;CPETRL2 antibody;Hs.84359 antibody

SEQUENCE SIMILARITIES

Belongs to the claudin family.

TISSUE SPECIFICITY

Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated.

SUBCELLULAR LOCATION

Cell membrane, Basolateral cell membrane, Cell junction, tight junction.

FUNCTION

Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. It belongs to the group of claudins.Claudins, such as CLDN7, are involved in the formation of tight junctions between epithelial cells. Tight junctions restrict lateral diffusion of lipids and membrane proteins, and thereby physically define the border between the apical and basolateral compartments of epithelial cells. It is expressed in kidney, lung and prostate. Claudin-7 is down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.