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Ctip2 Recombinant Rabbit Monoclonal Antibody [JF09-90] (ET1702-76)

Price: Regular price $385.00

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Catalog# ET1702-76

Rabbit Monoclonal to Ctip2

Tested for

  • WB

  • IHC-P

  • IHC-Fr

  • IF-Tissue

  • IF-Cell

Reacts with

  • Human

  • Mouse

  • Rat

  • Cynomolgus monkey

  • Pig

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Ctip2 Recombinant Rabbit Monoclonal Antibody [JF09-90] (ET1702-76)

Immunogen

Synthetic peptide within human ctip2 aa 491-534 / 894.

Host

Rabbit

Positive Control

LO2 cell lysate, THP-1 cell lysate, LO2, mouse brain tissue, human skin tissue, rat brain tissue, Jurkat.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JF09-90

RRID

AB_3070336

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IHC-P

  • 1:200-1:1,000

  • IHC-Fr

  • 1:1,000-1:2,000

  • IF-Tissue

  • 1:200-1:500

  • IF-Cell

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 96 kDa

Isotype

IgG

TARGET

UNIPROT #

Q9C0K0

PROTEIN NAME

Ctip2

SYNONYMS

ATL1 alpha antibody;ATL1 antibody;ATL1 beta antibody;ATL1 gamma antibody;ATL1-delta antibody;B cell CLL/lymphoma 11B/T cell receptor delta constant region fusion protein antibody;B cell lymphoma/leukemia 11B antibody;B-cell CLL/lymphoma 11B (zinc finger protein) antibody;B-cell CLL/lymphoma 11B antibody;B-cell lymphoma/leukemia 11B antibody;BC11B_HUMAN antibody;BCL-11B antibody;Bcl11b antibody;BCL11B/TRDC fusion antibody;COUP TF interacting protein 2 antibody;COUP-TF interacting protein 2 antibody;COUP-TF-interacting protein 2 antibody;Ctip 2 antibody;CTIP-2 antibody;CTIP2 antibody;hRIT1 alpha antibody;hRit1 antibody;Radiation induced tumor suppressor gene 1 antibody;Radiation induced tumor suppressor gene 1 protein antibody;Radiation-induced tumor suppressor gene 1 protein antibody;Rit 1 antibody;Rit1 antibody;zinc finger protein hRit1 alpha antibody;ZNF856B antibody

TISSUE SPECIFICITY

Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.

POST-TRANSLATIONAL MODIFICATION

Sumoylated with SUMO1.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.

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