CYP3A4 Recombinant Rabbit Monoclonal Antibody [JA11-33] (ET1704-88)

UNIPROT #

P08684

PROTEIN NAME

Cytochrome P450 3A4

SYNONYMS

1,8-cineole 2-exo-monooxygenase antibody;Albendazole monooxygenase antibody;Albendazole sulfoxidase antibody;CP33 antibody;CP34 antibody;CP3A4_HUMAN antibody;CYP3 antibody;CYP3A antibody;CYP3A3 antibody;CYP3A4 antibody;CYPIIIA3 antibody;CYPIIIA4 antibody;Cytochrome P450 3A3 antibody;Cytochrome P450 3A4 antibody;Cytochrome P450 family 3 subfamily A polypeptide 4 antibody;Cytochrome P450 HLp antibody;Cytochrome P450 NF-25 antibody;Cytochrome P450 subfamily IIIA polypeptide 4 antibody;cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 antibody;cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 antibody;Cytochrome P450-PCN1 antibody;Glucocorticoid inducible P450 antibody;HLP antibody;MGC126680 antibody;NF 25 antibody;NF25 antibody;Nifedipine oxidase antibody;P450 III steroid inducible antibody;P450 PCN1 antibody;P450, family III antibody;P450C3 antibody;P450PCN1 antibody;Quinine 3 monooxygenase antibody;Quinine 3-monooxygenase antibody;Taurochenodeoxycholate 6 alpha hydroxylase antibody;Taurochenodeoxycholate 6-alpha-hydroxylase antibody

SEQUENCE SIMILARITIES

Belongs to the cytochrome P450 family.

TISSUE SPECIFICITY

Expressed in prostate and liver. According to some authors, it is not expressed in brain. According to others, weak levels of expression are measured in some brain locations. Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).

POST-TRANSLATIONAL MODIFICATION

Polyubiquitinated in the presence of AMFR and UBE2G1 and also STUB1/CHIP and UBE2D1 (in vitro).

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane. Microsome membrane.

FUNCTION

CYP3A, the most abundant p450 enzyme in human liver, is responsible for the metabolism of more than 50% of the clinical test & lt; RTI ID = 0.0 & gt; (cYP3A) genes encode monooxygenases-enzymes which catalyze drug metabolism and the synthesis of cholesterol, steroids and other lipids. CYP3A family members localize in organs that associate with drug disposition, including the liver, gastrointestinal tract and kidney. The CYP3A cluster maps to gene locus 7q22.1 and consists of four genes (CYP3A4, CYP3A5, CYP3A7 and CYP3A43) and two pseudogenes ( CYP3A4 is abundant in the endoplasmic reticulum of liver cells and upper intestinal enterocytes. CYP3A4 expression is isducible by glucocorticoids pharmacological agents.